The Research
Psilocybin has been studied at major medical centers for more than two decades. Here’s what the strongest trials have found — in plain language, with links to the studies themselves. We point you to the evidence rather than oversell it: it’s a tool, not a cure, and the research says as much.
Depression lifts — and holds.
In a Johns Hopkins trial, two psilocybin sessions with therapy produced rapid, large drops in depression. A follow-up found the benefit lasted up to a year for many.
Davis et al. · JAMA Psychiatry · 2021
Read the study →Even when nothing else had worked.
In the largest psilocybin trial to date, a single 25 mg dose eased treatment-resistant depression within three weeks, with response lasting up to twelve.
Goodwin et al. · New England Journal of Medicine · 2022
Read the study →Relief facing the hardest diagnosis.
For people with life-threatening cancer, a single session sharply reduced anxiety and depression — with relief still measurable six to eight months later.
Ross / Griffiths · Journal of Psychopharmacology · 2016
Read the study →Loosening alcohol’s grip.
Paired with therapy, psilocybin cut heavy-drinking days in adults with alcohol use disorder, compared with placebo.
Bogenschutz et al. · JAMA Psychiatry · 2022
Read the study →Oregon built the first state-regulated system in the country for supervised adult psilocybin use. Every session at Vital Reset happens inside it.
Promising isn’t the same as proven for everyone. At screening we’ll tell you what the research does — and doesn’t — show for your situation.